LUCA Science Announces Oral Presentations at the World Mitochondria Society (WMS) 2022 Annual Meeting
LUCA Science (LUCA), a pre-clinical stage biotechnology company pioneering a new class of mitochondrial therapy, today announced the company will give oral presentations at the upcoming WMS Annual meeting 2022 – Targeting Mitochondria in Berlin, Germany on October 27, 2022 from 14:00 (CET).
LUCA will provide the characterization and anti-inflammatory effect of its proprietary mitochondria (Q) isolated by intact Mitochondria Isolation Technology (iMIT) in the oral presentations. LUCA’s collaborator Dr. Yoshihiro Ohta, Associate Professor at Tokyo University of Agriculture and Technology, will present the iMIT method following LUCA’s presentations.
LUCA’s presentation details are as follows:
Session Title: Mitochondria Transplantation and Transfer
1. Characterization of Frozen Mitochondria Isolated by Novel Method
This presentation highlights that Q can be stored in freezing conditions while maintaining high quality, compared to homogenized mitochondria isolated by using commercial mitochondria isolation kits. Even after undergoing freeze storage and thawing, Q demonstrated high production of ATP and preserved outer/inner membrane integrity by the measurement of cytochrome C oxidase and citrate synthase activity. Incorporation of Q into recipient cells after incubation for 24 hours was also higher demonstrated by higher exogenous mtDNA count using qPCR.
2. Anti-inflammatory Effect of Mitochondria Isolated by a Novel Method in Macrophage-like THP-1 Cells
This presentation highlights that mitochondria Q-incorporated human M0 THP-1 cells demonstrated dose-dependent anti-inflammatory effect by promoting ATP production and modulating LPS-simulated cytokine secretion (IL-1β and IL-6).
For more information on WMS, see here: